il-4 can inhibit il-17 production in collagen induced arthritis

نویسندگان

siamak sandoghchian shotorbani

department of immunology, jiangsu university, zhenjiang, china yue zhang

nanjing province people hospital, nanjing, china samuel essien baidoo

department of immunology, jiangsu university, zhenjiang, china huaxi xu

department of immunology, jiangsu university, zhenjiang, china mohammad ahmadi

چکیده

background: il-4 is a cytokine that induces differentiation of naive helper t cells into th2 cells. once activated by il-4, th2 cells subsequently produce additional il-4. objective: to examine the effect of il-4 on il-17 production and its effect in collagen- induced arthritis (cia) mice. method: in this study, a chicken collagen-ii-induced experimental arthritis (cia) model was used in dba/1 mice to investigate the relationship between il-4 and il-17 as well as other inflammatory factors. on the 38th day after the mice were induced with cia, the expression of il-17 and il-4 as well as ifn-γ and il-13 in sera of the mice was measured by qrt-pcr and elisa. result: the result of qrt-pcr analysis of il-17 and il-4 mrna levels in the spleen showed that il-17 is increased significantly at the onset of cia in the spleen (p

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IL-4 Can Inhibit IL-17 Production in Collagen Induced Arthritis

Background: IL-4 is a cytokine that induces differentiation of naive helper T cells into Th2 cells. Once activated by IL-4, Th2 cells subsequently produce additional IL-4. Objective: To examine the effect of IL-4 on IL-17 production and its effect in Collagen- Induced Arthritis (CIA) mice. Method: In this study, a chicken collagen-II-induced experimental arthritis (CIA) model was used in DBA/1 ...

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IL-4 can inhibit IL-17 production in collagen induced arthritis.

BACKGROUND IL-4 is a cytokine that induces differentiation of naive helper T cells into Th2 cells. Once activated by IL-4, Th2 cells subsequently produce additional IL-4. OBJECTIVE To examine the effect of IL-4 on IL-17 production and its effect in Collagen-Induced Arthritis (CIA) mice. METHOD In this study, a chicken collagen-II-induced experimental arthritis (CIA) model was used in DBA/1 ...

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عنوان ژورنال:
iranian journal of immunology

جلد ۸، شماره ۴، صفحات ۲۰۹-۲۱۷

کلمات کلیدی
[ ' c i a ' , ' i l ' , 4 , ' i l ' , 1 7 ]

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